t-Resveratrol Protects against Acute High Glucose Damage in Endothelial Cells

Leda Guzmán, Cristóbal Balada, Guillermo Flores, Rocío Álvarez, Marcela Knox, Raúl Vinet, José L. Martínez

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Postprandial hyperglycemia in diabetic and nondiabetic subjects is associated with endothelial dysfunction. Evidence shows that high glucose generates oxidative stress and a pro-inflammatory state promoting the development of cardiovascular diseases. trans-Resveratrol (t-RV) has been shown to reduce cardiovascular risk. To determine whether t-RV acts as a protector against acute high glucose (AHG)-induced damage, two in vitro models, rat aortic rings (RAR) and human umbilical vein endothelial cells (HUVEC) were used. RAR pretreated with AHG (25 mM D-glucose) for 3 h dramatically decreased the endothelium-dependent relaxation (EDR) induced by acetylcholine in phenylephrine (PE)-precontracted vessels. However, coincubation with t-RV significantly mitigated the damage induced by AHG on EDR. Pretreatment with AHG did not affect the vasodilation induced by sodium nitroprusside. HUVEC treated with t-RV decreased cytotoxicity and reduced radical oxygen species production induced by AHG. Taken together, these results suggest that t-RV can mitigate the AHG-induced EDR damage through a mechanism involving ROS scavenging and probably an increase in the bioavailability of NO.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalPlant Foods for Human Nutrition
Issue number3
StatePublished - 1 Sep 2018


  • Acute high glucose
  • Human umbilical vein endothelial cells
  • Oxidative stress
  • Postprandial hyperglycemia
  • Rat aorta
  • Resveratrol


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