Targeting Autophagy in Obesity-Associated Heart Disease

Diana Castañeda, Mohanad Gabani, Soo Kyoung Choi, Quynh My Nguyen, Cheng Chen, Ayesha Mapara, Adam Kassan, ALEXIS ANTONIO GONZALEZ PARRA, Karima Ait-Aissa, Modar Kassan

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Over the past three decades, the increasing rates of obesity have led to an alarming obesity epidemic worldwide. Obesity is associated with an increased risk of cardiovascular diseases; thus, it is essential to define the molecular mechanisms by which obesity affects heart function. Individuals with obesity and overweight have shown changes in cardiac structure and function, leading to cardiomyopathy, hypertrophy, atrial fibrillation, and arrhythmia. Autophagy is a highly conserved recycling mechanism that delivers proteins and damaged organelles to lysosomes for degradation. In the hearts of patients and mouse models with obesity, this process is impaired. Furthermore, it has been shown that autophagy flux restoration in obesity models improves cardiac function. Therefore, autophagy may play an important role in mitigating the adverse effects of obesity on the heart. Throughout this review, we will discuss the benefits of autophagy on the heart in obesity and how regulating autophagy might be a therapeutic tool to reduce the risk of obesity-associated cardiovascular diseases.

Original languageEnglish
Pages (from-to)1050-1058
Number of pages9
JournalObesity
Volume27
Issue number7
DOIs
StatePublished - 1 Jul 2019

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