TY - JOUR
T1 - The genetics of exceptional longevity
T2 - Insights from centenarians
AU - Santos-Lozano, Alejandro
AU - Santamarina, Ana
AU - Pareja-Galeano, Helios
AU - Sanchis-Gomar, Fabian
AU - Fiuza-Luces, Carmen
AU - Cristi-Montero, Carlos
AU - Bernal-Pino, Aranzazu
AU - Lucia, Alejandro
AU - Garatachea, Nuria
N1 - Publisher Copyright:
© 2016 Elsevier Ireland Ltd
PY - 2016
Y1 - 2016
N2 - As the world population ages, so the prevalence increases of individuals aged 100 years or more, known as centenarians. Reaching this age has been described as exceptional longevity (EL) and is attributed to both genetic and environmental factors. Many genetic variations known to affect life expectancy exist in centenarians. This review of studies conducted on centenarians and supercentenarians (older than 110 years) updates knowledge of the impacts on longevity of the twenty most widely investigated single nucleotide polymorphisms (SNPs).
AB - As the world population ages, so the prevalence increases of individuals aged 100 years or more, known as centenarians. Reaching this age has been described as exceptional longevity (EL) and is attributed to both genetic and environmental factors. Many genetic variations known to affect life expectancy exist in centenarians. This review of studies conducted on centenarians and supercentenarians (older than 110 years) updates knowledge of the impacts on longevity of the twenty most widely investigated single nucleotide polymorphisms (SNPs).
KW - Genetics
KW - Longevity
UR - http://www.scopus.com/inward/record.url?scp=84979200938&partnerID=8YFLogxK
U2 - 10.1016/j.maturitas.2016.05.006
DO - 10.1016/j.maturitas.2016.05.006
M3 - Review article
C2 - 27282794
AN - SCOPUS:84979200938
SN - 0378-5122
VL - 90
SP - 49
EP - 57
JO - Maturitas
JF - Maturitas
ER -
