The genetics of exceptional longevity: Insights from centenarians

Alejandro Santos-Lozano, Ana Santamarina, Helios Pareja-Galeano, Fabian Sanchis-Gomar, Carmen Fiuza-Luces, Carlos Cristi-Montero, Aranzazu Bernal-Pino, Alejandro Lucia, Nuria Garatachea

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


As the world population ages, so the prevalence increases of individuals aged 100 years or more, known as centenarians. Reaching this age has been described as exceptional longevity (EL) and is attributed to both genetic and environmental factors. Many genetic variations known to affect life expectancy exist in centenarians. This review of studies conducted on centenarians and supercentenarians (older than 110 years) updates knowledge of the impacts on longevity of the twenty most widely investigated single nucleotide polymorphisms (SNPs).

Original languageEnglish
Pages (from-to)49-57
Number of pages9
StatePublished - 2016


  • Genetics
  • Longevity


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