The Wnt and BMP families of signaling morphogens at the vertebrate neuromuscular junction

Juan P. Henríquez, Catherine E. Krull, Nelson Osses

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

The neuromuscular junction has been extensively employed in order to identify crucial determinants of synaptogenesis. At the vertebrate neuromuscular synapse, extracellular matrix and signaling proteins play stimulatory and inhibitory roles on the assembly of functional synapses. Studies in invertebrate species have revealed crucial functions of early morphogens during the assembly and maturation of the neuromuscular junction. Here, we discuss growing evidence addressing the function of Wnt and Bone morphogenetic protein (BMP) signaling pathways at the vertebrate neuromuscular synapse. We focus on the emerging role of Wnt proteins as positive and negative regulators of postsynaptic differentiation. We also address the possible involvement of BMP pathways on motor neuron behavior for the assembly and/or regeneration of the neuromuscular junction.

Original languageEnglish
Pages (from-to)8924-8946
Number of pages23
JournalInternational Journal of Molecular Sciences
Volume12
Issue number12
DOIs
StatePublished - Dec 2011
Externally publishedYes

Keywords

  • BMP
  • Neuromuscular junction
  • Wnt

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