Propiedad vasodilatadora de solanum crispum Ruiz & Pav. Una planta nativa de américa de sur

Translated title of the contribution: Vasodilatory properties of Solanum crispum Ruiz & Pav. A South American native plant

Raúl Vinet, Rocío Álvarez, Marcela Knox, LEDA MARCELA GUZMAN MALUENDA, José L. Martínez, Eva Flores

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Solatium crispum Ruiz & Pav. (S. crispum) is a southern South American native plant that is usually used in traditional medicine for the treatment of symptoms associated with both, acute and chronic ailments. Enema and infusion of leaves and stems are used to treat fever, headache, inflammation and hypertension. In this study, we aim to assess the vasoactive effect of hydroalcoholic extracts of S. crispum on isolated rat aorta rings. The hydroalcoholic extract of S. crispum induced a vasodilatory effect (42.6 ± 4.1%) in aortic rings precontracted with phenylephrine (0.1 μM). The aortic relaxation was largely endothelium-dependent and mediated by nitric oxide (NO). The endothelium- and NO-dependence was demonstrated by a drastic fall in the dilatation induced by the extract when the endothelium was removed (10.6 ± 2.3%) and when nitric oxide synthase (NOS) was inhibited (12.3 ± 2.5%) by nitro-L-arginine (L-NNA). This result supports the popular use of S. crispum in the treatment of hypertension that may be due, at least in part, to the vasodilator effect of one o more compounds present in their leaves and stems. Further studies should be performed to clarify this phenomenon.

Translated title of the contributionVasodilatory properties of Solanum crispum Ruiz & Pav. A South American native plant
Original languageSpanish
Pages (from-to)94-98
Number of pages5
JournalBoletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
Issue number2
StatePublished - Mar 2016
Externally publishedYes

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