What goes around comes around: Novel pharmacological targets in the gut-brain axis

Camila González-Arancibia, Jorge Escobar-Luna, Camila Barrera-Bugueño, Camilo Díaz-Zepeda, María P. González-Toro, Loreto Olavarría-Ramírez, Francesca Zanelli-Massai, Martin Gotteland, Javier A. Bravo, MARCELA JULIO PIEPER

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

The gut and the brain communicate bidirectionally through anatomic and humoral pathways, establishing what is known as the gut-brain axis. Therefore, interventions affecting one system will impact on the other, giving the opportunity to investigate and develop future therapeutic strategies that target both systems. Alterations in the gut-brain axis may arise as a consequence of changes in microbiota composition (dysbiosis), modifications in intestinal barrier function, impairment of enteric nervous system, unbalanced local immune response and exaggerated responses to stress, to mention a few. In this review we analyze and discuss several novel pharmacological targets within the gut-brain axis, with potential applications to improve intestinal and mental health.

Original languageEnglish
Pages (from-to)339-353
Number of pages15
JournalTherapeutic Advances in Gastroenterology
Volume9
Issue number3
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • enteric nervous system
  • gut-brain axis
  • interleukin 22
  • intestinal microbiota
  • serotonin
  • vagus nerve

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