A polyphenol-rich Calafate (Berberis microphylla) extract rescues glucose tolerance in mice fed with cafeteria diet

J. Soto-Covasich, M. Reyes-Farias, R. F. Torres, K. Vasquez, L. Duarte, J. Quezada, P. Jimenez, M. T. Pino, L. Garcia-Nannig, LUIS ALBERTO MERCADO VIANCO, D. F. Garcia-Diaz

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

9 Citas (Scopus)

Resumen

The establishment of a chronic inflammatory state in the adipose tissue contributes to obesity-associated insulin resistance. Hence, disrupting the inflammatory response elicited by obesity remains a relevant target to tackle the modern-world pandemic. We evaluated the anti-inflammatory and insulin-sensitizing effect of Calafate (Berberis microphylla) by producing and characterizing a polyphenol-pure Calafate extract (PPCE). C57BL/6 mice fed with cafeteria diet for 14 weeks were administered PPCE (50 mg/Kg/day) for 4 weeks. PPCE administration rescued glucose tolerance and insulin-elicited AKT phosphorylation in white adipose tissue of diet-induced insulin-resistant mice. Furthermore, the cafeteria diet-induced expression of TNF-alpha and F4/80 was attenuated by PPCE administration, suggesting that PPCE rescues insulin sensibility by ameliorating the obesity-associated inflammatory state. Altogether, our data shows that Calafate represents a natural source of polyphenols with glucose tolerance-improving properties in vivo, suggesting a potential use of PPCE as a complementary tool against insulin resistance.

Idioma originalInglés
Número de artículo103856
PublicaciónJournal of Functional Foods
Volumen67
DOI
EstadoPublicada - abr. 2020
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'A polyphenol-rich Calafate (Berberis microphylla) extract rescues glucose tolerance in mice fed with cafeteria diet'. En conjunto forman una huella única.

Citar esto