Amiloride fluxes across erythrocyte membranes

Dale J. Benos, Juan Reyes, David G. Shoemaker

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

23 Citas (Scopus)

Resumen

Amiloride is known to inhibit both the influx of Na+ and the activation of mitogensis in many cultured cell lines. This paper describes experiments in which the permeability coefficient of amiloride was determined from measurements of tracer fluxes across human erythrocytes and resealed ghosts. From an analysis of these fluxes, a permeability coefficient of 10-7 cm/s for the uncharged form of amiloride was deduced. Based upon this measured permeability value, we present calculations of intracellular accumulation times of amiloride in cells of differing surface-to-volume ratio.

Idioma originalInglés
Páginas (desde-hasta)99-104
Número de páginas6
PublicaciónBiochimica et Biophysica Acta - Biomembranes
Volumen734
N.º1
DOI
EstadoPublicada - 21 sep 1983
Publicado de forma externa

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