Antioxidant and anti-cancer activities of brown and red seaweed extracts from chilean coasts

Alejandra Miranda-Delgado, María José Montoya, Marilyn Paz-Araos, Marco Mellado, Joan Villena, Paulina Arancibia, Alejandro Madrid, Carlos Jara-Gutiérrez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

16 Citas (Scopus)

Resumen

This study evaluates the content of polyphenols, flavonoids and anthraquinones from sequential extracts from four algae species from along the Chilean coastline: Desmarestia ligulata, Dictyota kunthii, Laurencia chilensis and Chondracanthus chamissoi. The antioxidant capacity of these extracts was evaluated through three complementary assays: the TRAP, FRAP, and DPPH assays. Additionally, the cytotoxic activity of these extracts was determined through sulforhodamine B assays on two cancer cell lines, one colon (HT-29) and one breast (MCF-7), and one non-tumor control group of epithelial colon cells (CoN). The greatest antioxidant activity was detected in the ethyl acetate and dichloromethane extracts from L. chilensis in its TRAP potential, ethyl acetate of D. kunthii in its FRAP potential, and finally D. ligulata in its DPPH radical scavenging activity. The activities of this D. ligulata and L. chilensis extracts were significantly correlated with their flavonoid contents. In addition, the dichloromethane extracts from D. kunthii and C. chamissoi showed strong cytotoxic activity against HT-29 and MCF-7; however, the activity was not selective. Future research is necessary to purify the bioactive compounds of interest and improve their selectivity for eventual therapeutic use.

Idioma originalInglés
Páginas (desde-hasta)301-313
Número de páginas13
PublicaciónLatin American Journal of Aquatic Research
Volumen46
N.º2
DOI
EstadoPublicada - 2018
Publicado de forma externa

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