Carveoylphenols and their antifungal potential against pathogenic yeasts

Iván Montenegro, MARCO ANDRÉS MELLADO GARCÍA, Alessandra Russo, Bastian Said, XIMENA ALEJANDRA BESOAIN CANALES, Patricio Godoy, Enrique Werner, Nelson Caro, Alejandro Madrid

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

4 Citas (Scopus)

Resumen

Candida is a genus of yeasts and is the most common cause of fungal infections worldwide. However, only a few antifungal drugs are currently available for the treatment of Candida infections. In the last decade, terpenophenols have attracted much attention because they often possess a variety of biological activities. In the search for new antifungals, eight carveoylphenols were synthesized and characterized by spectroscopic analysis. By using the broth microdilution assay, the compounds were evaluated for antifungal activities in vitro against four human pathogenic yeast, and structure–activity relationships (SAR) were derived. Noteworthy, in this preliminary study, compounds 5 and 6, have shown a significant reduction in the growth of all Candida strains tested. Starting from these preliminary results, we have designed the second generation of analogous in this class, and further studies are in progress in our laboratories.

Idioma originalInglés
Número de artículo185
PublicaciónAntibiotics
Volumen8
N.º4
DOI
EstadoPublicada - dic. 2019
Publicado de forma externa

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