DNA methylation in Trypanosoma cruzi

M. Véronica Rojas; Norbel Galanti

doi:10.1016/0014-5793(90)80717-W

DNA methylation in Trypanosoma cruzi

M. Véronica Rojas, Norbel Galanti

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

19 Citas (Scopus)

Resumen

DNA isolated from the protozoan Trypanosoma cruzi has been found to contain 5-methylcytosine. Analysis of T. cruzi DNA by both HpaII and MspI restriction endonucleases suggests that the sequence -CCGG- is not methylated. Probably T. cruzi DNA also contains N⁶-methyladenine. This report constitutes the first clear demonstration of the presence of methylated bases in the nuclear DNA from trypanosomes.

Idioma original	Inglés
Páginas (desde-hasta)	113-116
Número de páginas	4
Publicación	FEBS Letters
Volumen	263
N.º	1
DOI	https://doi.org/10.1016/0014-5793(90)80717-W
Estado	Publicada - 9 abr. 1990
Publicado de forma externa	Sí

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abstract = "DNA isolated from the protozoan Trypanosoma cruzi has been found to contain 5-methylcytosine. Analysis of T. cruzi DNA by both HpaII and MspI restriction endonucleases suggests that the sequence -CCGG- is not methylated. Probably T. cruzi DNA also contains N6-methyladenine. This report constitutes the first clear demonstration of the presence of methylated bases in the nuclear DNA from trypanosomes.",

keywords = "5-Methylcytosine, Base composition, DNA methylation, Trypanosoma cruzi",

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AB - DNA isolated from the protozoan Trypanosoma cruzi has been found to contain 5-methylcytosine. Analysis of T. cruzi DNA by both HpaII and MspI restriction endonucleases suggests that the sequence -CCGG- is not methylated. Probably T. cruzi DNA also contains N6-methyladenine. This report constitutes the first clear demonstration of the presence of methylated bases in the nuclear DNA from trypanosomes.

KW - 5-Methylcytosine

KW - Base composition

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KW - Trypanosoma cruzi

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DNA methylation in Trypanosoma cruzi

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