Encapsulación de células usando quitosano: Aspectos químicos y aplicaciones

Maura Rojas Pirela, Verónica Rojas, Elizabeth Pérez Pérez, Cristóbal Lárez Velásquez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

In this work, the main approaches for the preparation of encapsulating matrices using chitosan-containing formulations have been reviewed. Various methodologies have been considered, such as physical intermolecular bonds and chemical cross-linking reactions, including the click reactions which have become novel in the cross-linking of systems containing this biopolymer. Likewise, the formation of different macroscopic assemblies such as spheroids, vesicles, layer by layer polycomplexes, etc., has been addressed. In the final part of the work, the main achievements reported with these matrices in the encapsulation of cells, both eukaryotic and prokaryotic, are discussed, emphasizing their potential applications and perspectives in different fields as medicine (treatment of traumatic diseases, diabetes, venous diseases, tissue regeneration, transplantation and tolerance); food (administration of probiotics); industrial applications (bioethanol production); etc.

Título traducido de la contribuciónCell encapsulation using chitosan: Chemical aspects and applications
Idioma originalEspañol
Páginas (desde-hasta)89-103
Número de páginas15
PublicaciónAvances en Quimica
Volumen16
N.º3
EstadoPublicada - 2021
Publicado de forma externa

Palabras clave

  • Cell encapsulating matrices
  • Chemical crosslinking
  • Click reaction
  • Ionotropic gelation

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