Facile Approach to Covalent Copolypeptide Hydrogels and Hybrid Organohydrogels

Saltuk B. Hanay, Joanne O'Dwyer, Scott D. Kimmins, Fernando C.S. De Oliveira, Matthew G. Haugh, Fergal J. O'Brien, Sally Ann Cryan, Andreas Heise

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

11 Citas (Scopus)

Resumen

Crosslinking of tryptophan (Trp) containing copolypeptides with varying ratios of benzyl-l-glutamate (BLG) and Nα-(carbobenzyloxy)-l-lysine (Z-Lys) is achieved by the selective reaction with hexamethylene-bis-TAD (bisTAD). Conversion of the resulting organogels into biocompatible hydrogels by full BLG or Z-Lys deprotection is demonstrated. Moreover, diffusion controlled deprotection allows the design of macroscopic hybrid organohydrogels comprising hydrophilic as well as hydrophobic regions at a desired ratio and position. FTIR and SEM analysis confirm the coexistence of both hydrophilic and hydrophobic segments in one copolypeptide piece. Selective loading of hydrogel and organogel segments with hydrophilic and hydrophobic dyes, respectively, is observed on macroscopic amphiphilic gels and films. These materials offer significant potential as dual-loaded drug release gels as well as tissue engineering platforms.

Idioma originalInglés
Páginas (desde-hasta)944-949
Número de páginas6
PublicaciónACS Macro Letters
Volumen7
N.º8
DOI
EstadoPublicada - 21 ago. 2018
Publicado de forma externa

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