Fluids are suspected to play a major role in the nucleation and rupture propagation of earthquakes. In Chile, seismological data were previously interpreted to indicate that fluids captured in the fault zone are released periodically during large underthrust earthquakes, leading to post-seismic fluid flow. In central Chile, heat flow derived from the presence of a bottom simulating reflector (BSR) show a smooth trend across the margin. BSR-derived data are in excellent agreement with thermal subduction zone models. Over the young accretionary prism, both BSR-derived and measured surface heat flow support a common trend. Landwards of the backstop, however, measured heat flow triples over a distance of 20-30 km, producing a profound discrepancy to the BSR-derived data. We suggest that this disparity is related to transient flow of warm fluids through the gas hydrate stability zone possibly caused by fluids released after large underthrust earthquakes. Such flow events may inherently affect the distribution of solid gas hydrates between the seafloor and the BSR.