Métodos de integración de odds ratio basados en meta-análisis usando modelos de efectos fijos y aleatorios útiles en salud pública

Mónica Catalán, M. Purificación Galindo, Javier Martín, Víctor Leiva

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

Resumen

Meta-analysis integrates information from different studies to generate a common response to a determined problem. In the literature, we find several integration methods of results, with the integration method of levels of probability being the more basic and, with a greater complexity, the integration method of the effect size, which uses fixed and random effect models. In this study, we compare the results of two estimation methods of the effect size based on meta-analysis using fixed and random effect models. The measure of the effect size considered here is the odds ratio, due to this measure is frequently used in systematic reviews of several topics of interest in public health, such as heart diseases, laparoscopic colectomy, Parkinson disease, tobacco addiction and uterine cervical cancer. Conclusions of this work indicate the applicability conditions of the analyzed estimators of the odds ratio in function of the size of the population effect, of the variability among studies, of the size of the meta-analysis and of the sample sizes of such studies.

Título traducido de la contribuciónIntegration methods of odds ratio based on meta-analysis using fixed and random effect models useful in public health
Idioma originalEspañol
Páginas (desde-hasta)205-222
Número de páginas18
PublicaciónRevista Colombiana de Estadistica
Volumen35
N.º2 SPEC. ISSUE
EstadoPublicada - 2012
Publicado de forma externa

Palabras clave

  • Biostatistics
  • Clinical trials
  • Effect size
  • Medicine

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