Mineralocorticoids modulate the expression of the β-3 subunit of the Na+, K+-ATPase in the renal collecting duct

Macarena Rojas, Pablo Díaz, Pablo León, Alexis A. Gonzalez, Magdalena González, Víctor Barrientos, Nikolay B. Pestov, Rodrigo Alzamora, Luis Michea

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Renal sodium reabsorption depends on the activity of the Na+,K+-ATPase α/β heterodimer. Four α (α1–4) and 3 β (β1–3) subunit isoforms have been described. It is accepted that renal tubule cells express α11 dimers. Aldosterone stimulates Na+,K+-ATPase activity and may modulate α11 expression. However, some studies suggest the presence of β3 in the kidney. We hypothesized that the β3 isoform of the Na+,K+-ATPase is expressed in tubular cells of the distal nephron, and modulated by mineralocorticoids. We found that β3 is highly expressed in collecting duct of rodents, and that mineralocorticoids decreased the expression of β3. Thus, we describe a novel molecular mechanism of sodium pump modulation that may contribute to the effects of mineralocorticoids on sodium reabsorption.

Idioma originalInglés
Páginas (desde-hasta)388-398
Número de páginas11
PublicaciónChannels
Volumen11
N.º5
DOI
EstadoPublicada - 3 sept. 2017
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Mineralocorticoids modulate the expression of the β-3 subunit of the Na+, K+-ATPase in the renal collecting duct'. En conjunto forman una huella única.

Citar esto