TY - JOUR
T1 - Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules
T2 - Toward a Rational Nanoarchitectural Design of Hybrid Materials
AU - Goel, Keshav
AU - Zuñiga-Bustos, Matias
AU - Lazurko, Caitlin
AU - Jacques, Erik
AU - Galaz-Araya, Constanza
AU - Valenzuela-Henriquez, Francisco
AU - Pacioni, Natalia L.
AU - Couture, Jean François
AU - Poblete, Horacio
AU - Alarcon, Emilio I.
N1 - Funding Information:
This work was made possible by funding from the Natural Sciences and Engineering Research Council (NSERC) RGPIN-2015-0632, to the Canadian Institutes of Health Sciences (CIHR) to EIA. J.-F.C. is supported by an NSERC (RGPIN-2015-06503) and two CIHR grants (PJT-148869 and PJT-148533). H.P. is grateful for FONDECYT grant no. 1171155 as well as the Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), which is the Millennium Nucleus supported by the Iniciativa Cientifica Milenio of the Ministry of Economy, Development and Tourism (Chile). N.L.P. thanks Secyt-UNC for grant Res. 411/18. K.G. is appreciative to the Natural Sciences and Engineering Research Council Undergraduate Student Research Award. C.L. is thankful for the Queen Elizabeth II Graduate Scholarship in Science and Technology. We thank Perfilieva et al., for kindly facilitating the 6 nm octahedron gold model.
Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/5/15
Y1 - 2019/5/15
N2 - The effect of accounting for the total surface in the association of thiol-containing molecules to nanosilver was assessed using isothermal titration calorimetry, along with a new open access algorithm that calculates the total surface area for samples of different polydispersity. Further, we used advanced molecular dynamic calculations to explore the underlying mechanisms for the interaction of the studied molecules in the presence of a nanosilver surface in the form of flat surfaces or as three-dimensional pseudospherical nanostructures. Our data indicate that not only is the total surface area available for binding but also the supramolecular arrangements of the molecules in the near proximity of the nanosilver surface strongly affects the affinity of thiol-containing molecules to nanosilver surfaces.
AB - The effect of accounting for the total surface in the association of thiol-containing molecules to nanosilver was assessed using isothermal titration calorimetry, along with a new open access algorithm that calculates the total surface area for samples of different polydispersity. Further, we used advanced molecular dynamic calculations to explore the underlying mechanisms for the interaction of the studied molecules in the presence of a nanosilver surface in the form of flat surfaces or as three-dimensional pseudospherical nanostructures. Our data indicate that not only is the total surface area available for binding but also the supramolecular arrangements of the molecules in the near proximity of the nanosilver surface strongly affects the affinity of thiol-containing molecules to nanosilver surfaces.
KW - association models
KW - cystein-containing peptides
KW - isothermal titration calorimetry
KW - molecular dynamics
KW - nanosurface engineering
KW - polydispersity
KW - silver nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85065980618&partnerID=8YFLogxK
U2 - 10.1021/acsami.9b03942
DO - 10.1021/acsami.9b03942
M3 - Article
C2 - 31013043
AN - SCOPUS:85065980618
SN - 1944-8244
VL - 11
SP - 17697
EP - 17705
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 19
ER -