The Global Emissions Initiative (GEIA) stores and offers global datasets of emission inventories developed in the last 30 years. One of the most recently updated global datasets covering anthropogenic source emissions is the Copernicus Atmosphere Monitoring Service (CAMS). This study applied NetCDF Command Operator (NCO) software to preprocess the anthropogenic sources included in the CAMS datasets and converted those files as an input in the Sparse Matrix Operator Kerner Emissions (SMOKE) model for future air quality modeling. As a result, six steps were applied to obtain the required file format. The case of the central coast in Chile was analyzed to compare the global database and official reports for the on-road transport sector. As a result, some differences were shown in the most populated locations of the domain of analysis. The rest of the zones registered similar values. The methodology exposed in this report could be applied in any other region of the planet for air quality modeling studies. The development of global datasets such as CAMS is useful for hemispheric analysis and could bring an estimation on the mesoscale. It represents an opportunity for those locations without official reports of non-updated data. • This study applied NCO commands available for the preprocessing of the CAMS dataset files. • The emissions and temporal profile registered in CAMS datasets must be compared to official reports of transport sectors. • The development of global datasets such as CAMS is useful for hemispheric analysis and could bring an estimation on the mesoscale.