TY - JOUR
T1 - Sustained acclimatization in Chilean mine workers subjected to chronic intermittent hypoxia
AU - Farias, Jorge G.
AU - Osorio, Jorge
AU - Soto, Gustavo
AU - Brito, Julio
AU - Siques, Patricia
AU - Reyes, Juan G.
PY - 2006/12
Y1 - 2006/12
N2 - We wanted to know if sea-level mine workers exposed previously to chronic intermittent hypoxia reached a steady acclimatization at 36 months under hypobaric hypoxia. An intermittently exposed group of mine workers (IE, n = 25) were subjected to submaximal exercise (100 W) at 4500 m. Their systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and hemoglobin oxygen saturation (HbSatO2) were monitored. Two comparison groups of unacclimatized sea-level workers (n = 17) were studied. A nonexposed group (NE) performed 5 min of submaximal exercise at sea level. Some kind of exercise was performed both by an acutely exposed group (AE) and IE group at 4500 m. No statistical differences were found for HR, SBP, and DBP (p > 0.05) during exercise between IE and AE groups. Resting HbSatO2 of IE (87 ± 6%) was lower than NE (97 ± 3%) (p < 0.05), but was higher than AE (82 ± 4%) (p < 0.05). Tn the exercise condition, HbSatO2 of IE (85 ± 5%) was lower than NE (95 ± 3%) (p < 0.05), but was higher than AE (76 ± 2%) (p < 0.05). These responses were maintained through the 6 months of the study period. Thus, mine workers subjected to intermittent hypobaric condition for 3 years showed a good degree of acclimatization that was maintained through time.
AB - We wanted to know if sea-level mine workers exposed previously to chronic intermittent hypoxia reached a steady acclimatization at 36 months under hypobaric hypoxia. An intermittently exposed group of mine workers (IE, n = 25) were subjected to submaximal exercise (100 W) at 4500 m. Their systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and hemoglobin oxygen saturation (HbSatO2) were monitored. Two comparison groups of unacclimatized sea-level workers (n = 17) were studied. A nonexposed group (NE) performed 5 min of submaximal exercise at sea level. Some kind of exercise was performed both by an acutely exposed group (AE) and IE group at 4500 m. No statistical differences were found for HR, SBP, and DBP (p > 0.05) during exercise between IE and AE groups. Resting HbSatO2 of IE (87 ± 6%) was lower than NE (97 ± 3%) (p < 0.05), but was higher than AE (82 ± 4%) (p < 0.05). Tn the exercise condition, HbSatO2 of IE (85 ± 5%) was lower than NE (95 ± 3%) (p < 0.05), but was higher than AE (76 ± 2%) (p < 0.05). These responses were maintained through the 6 months of the study period. Thus, mine workers subjected to intermittent hypobaric condition for 3 years showed a good degree of acclimatization that was maintained through time.
KW - Adaptation
KW - Cardiovascular response
KW - Exercise
KW - Oxygen saturation
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=33846197825&partnerID=8YFLogxK
U2 - 10.1089/ham.2006.7.302
DO - 10.1089/ham.2006.7.302
M3 - Article
C2 - 17173515
AN - SCOPUS:33846197825
SN - 1527-0297
VL - 7
SP - 302
EP - 306
JO - High Altitude Medicine and Biology
JF - High Altitude Medicine and Biology
IS - 4
ER -