Synthesis and anti-saprolegnia activity of new 2’,4’-dihydroxydihydrochalcone derivatives

Enrique Werner, Iván Montenegro, Bastian Said, Patricio Godoy, XIMENA ALEJANDRA BESOAIN CANALES, Nelson Caro, Alejandro Madrid

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

In the present study, seven 2’,4’-dihydroxydihydrochalcone derivatives (compounds 3–9) were synthesized and their capacity as anti-Saprolegnia agents were evaluated against Saprolegnia parasitica, S. australis, S. diclina. Derivative 9 showed the best activity against the different strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values between 100–175 µg/mL and 100–200 µg/mL, respectively, compared with bronopol and fluconazole as positive controls. In addition, compound 9 caused damage and disintegration cell membrane of all Saprolegnia strains over the action of commercial controls.

Idioma originalInglés
Número de artículo317
Páginas (desde-hasta)1-8
Número de páginas8
PublicaciónAntibiotics
Volumen9
N.º6
DOI
EstadoPublicada - jun. 2020
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Synthesis and anti-saprolegnia activity of new 2’,4’-dihydroxydihydrochalcone derivatives'. En conjunto forman una huella única.

Citar esto