Synthesis and anti-saprolegnia activity of new 2’,4’-dihydroxydihydrochalcone derivatives

Enrique Werner; Iván Montenegro; Bastian Said; Patricio Godoy; Ximena Besoain; Nelson Caro; Alejandro Madrid

doi:10.3390/antibiotics9060317

Synthesis and anti-saprolegnia activity of new 2’,4’-dihydroxydihydrochalcone derivatives

Enrique Werner, Iván Montenegro, Bastian Said, Patricio Godoy, Ximena Besoain, Nelson Caro, Alejandro Madrid

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Resumen

In the present study, seven 2’,4’-dihydroxydihydrochalcone derivatives (compounds 3–9) were synthesized and their capacity as anti-Saprolegnia agents were evaluated against Saprolegnia parasitica, S. australis, S. diclina. Derivative 9 showed the best activity against the different strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values between 100–175 µg/mL and 100–200 µg/mL, respectively, compared with bronopol and fluconazole as positive controls. In addition, compound 9 caused damage and disintegration cell membrane of all Saprolegnia strains over the action of commercial controls.

Idioma original	Inglés
Número de artículo	317
Páginas (desde-hasta)	1-8
Número de páginas	8
Publicación	Antibiotics
Volumen	9
N.º	6
DOI	https://doi.org/10.3390/antibiotics9060317
Estado	Publicada - jun. 2020

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title = "Synthesis and anti-saprolegnia activity of new 2{\textquoteright},4{\textquoteright}-dihydroxydihydrochalcone derivatives",

abstract = "In the present study, seven 2{\textquoteright},4{\textquoteright}-dihydroxydihydrochalcone derivatives (compounds 3–9) were synthesized and their capacity as anti-Saprolegnia agents were evaluated against Saprolegnia parasitica, S. australis, S. diclina. Derivative 9 showed the best activity against the different strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values between 100–175 µg/mL and 100–200 µg/mL, respectively, compared with bronopol and fluconazole as positive controls. In addition, compound 9 caused damage and disintegration cell membrane of all Saprolegnia strains over the action of commercial controls.",

keywords = "2{\textquoteright},4{\textquoteright}-dihydroxydihydrochalcone, Anti-Saprolegnia activity, Lipophilicity, Oxyalkylated derivatives",

author = "Enrique Werner and Iv{\'a}n Montenegro and Bastian Said and Patricio Godoy and Ximena Besoain and Nelson Caro and Alejandro Madrid",

year = "2020",

month = jun,

doi = "10.3390/antibiotics9060317",

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T1 - Synthesis and anti-saprolegnia activity of new 2’,4’-dihydroxydihydrochalcone derivatives

AU - Werner, Enrique

AU - Montenegro, Iván

AU - Said, Bastian

AU - Godoy, Patricio

AU - Besoain, Ximena

AU - Caro, Nelson

AU - Madrid, Alejandro

PY - 2020/6

Y1 - 2020/6

N2 - In the present study, seven 2’,4’-dihydroxydihydrochalcone derivatives (compounds 3–9) were synthesized and their capacity as anti-Saprolegnia agents were evaluated against Saprolegnia parasitica, S. australis, S. diclina. Derivative 9 showed the best activity against the different strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values between 100–175 µg/mL and 100–200 µg/mL, respectively, compared with bronopol and fluconazole as positive controls. In addition, compound 9 caused damage and disintegration cell membrane of all Saprolegnia strains over the action of commercial controls.

AB - In the present study, seven 2’,4’-dihydroxydihydrochalcone derivatives (compounds 3–9) were synthesized and their capacity as anti-Saprolegnia agents were evaluated against Saprolegnia parasitica, S. australis, S. diclina. Derivative 9 showed the best activity against the different strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values between 100–175 µg/mL and 100–200 µg/mL, respectively, compared with bronopol and fluconazole as positive controls. In addition, compound 9 caused damage and disintegration cell membrane of all Saprolegnia strains over the action of commercial controls.

KW - 2’,4’-dihydroxydihydrochalcone

KW - Anti-Saprolegnia activity

KW - Lipophilicity

KW - Oxyalkylated derivatives

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DO - 10.3390/antibiotics9060317

M3 - Article

AN - SCOPUS:85088055384

SN - 2079-6382

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JO - Antibiotics

JF - Antibiotics

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Synthesis and anti-saprolegnia activity of new 2’,4’-dihydroxydihydrochalcone derivatives

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