Targeting Autophagy in Obesity-Associated Heart Disease

Diana Castañeda, Mohanad Gabani, Soo Kyoung Choi, Quynh My Nguyen, Cheng Chen, Ayesha Mapara, Adam Kassan, Alexis A. Gonzalez, Karima Ait-Aissa, Modar Kassan

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

18 Citas (Scopus)

Resumen

Over the past three decades, the increasing rates of obesity have led to an alarming obesity epidemic worldwide. Obesity is associated with an increased risk of cardiovascular diseases; thus, it is essential to define the molecular mechanisms by which obesity affects heart function. Individuals with obesity and overweight have shown changes in cardiac structure and function, leading to cardiomyopathy, hypertrophy, atrial fibrillation, and arrhythmia. Autophagy is a highly conserved recycling mechanism that delivers proteins and damaged organelles to lysosomes for degradation. In the hearts of patients and mouse models with obesity, this process is impaired. Furthermore, it has been shown that autophagy flux restoration in obesity models improves cardiac function. Therefore, autophagy may play an important role in mitigating the adverse effects of obesity on the heart. Throughout this review, we will discuss the benefits of autophagy on the heart in obesity and how regulating autophagy might be a therapeutic tool to reduce the risk of obesity-associated cardiovascular diseases.

Idioma originalInglés
Páginas (desde-hasta)1050-1058
Número de páginas9
PublicaciónObesity
Volumen27
N.º7
DOI
EstadoPublicada - jul. 2019

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