TY - JOUR
T1 - What goes around comes around
T2 - Novel pharmacological targets in the gut-brain axis
AU - González-Arancibia, Camila
AU - Escobar-Luna, Jorge
AU - Barrera-Bugueño, Camila
AU - Díaz-Zepeda, Camilo
AU - González-Toro, María P.
AU - Olavarría-Ramírez, Loreto
AU - Zanelli-Massai, Francesca
AU - Gotteland, Martin
AU - Bravo, Javier A.
AU - Julio-Pieper, Marcela
N1 - Publisher Copyright:
© 2016 The Author(s).
PY - 2016
Y1 - 2016
N2 - The gut and the brain communicate bidirectionally through anatomic and humoral pathways, establishing what is known as the gut-brain axis. Therefore, interventions affecting one system will impact on the other, giving the opportunity to investigate and develop future therapeutic strategies that target both systems. Alterations in the gut-brain axis may arise as a consequence of changes in microbiota composition (dysbiosis), modifications in intestinal barrier function, impairment of enteric nervous system, unbalanced local immune response and exaggerated responses to stress, to mention a few. In this review we analyze and discuss several novel pharmacological targets within the gut-brain axis, with potential applications to improve intestinal and mental health.
AB - The gut and the brain communicate bidirectionally through anatomic and humoral pathways, establishing what is known as the gut-brain axis. Therefore, interventions affecting one system will impact on the other, giving the opportunity to investigate and develop future therapeutic strategies that target both systems. Alterations in the gut-brain axis may arise as a consequence of changes in microbiota composition (dysbiosis), modifications in intestinal barrier function, impairment of enteric nervous system, unbalanced local immune response and exaggerated responses to stress, to mention a few. In this review we analyze and discuss several novel pharmacological targets within the gut-brain axis, with potential applications to improve intestinal and mental health.
KW - enteric nervous system
KW - gut-brain axis
KW - interleukin 22
KW - intestinal microbiota
KW - serotonin
KW - vagus nerve
UR - http://www.scopus.com/inward/record.url?scp=84963762016&partnerID=8YFLogxK
U2 - 10.1177/1756283X16630718
DO - 10.1177/1756283X16630718
M3 - Review article
AN - SCOPUS:84963762016
SN - 1756-283X
VL - 9
SP - 339
EP - 353
JO - Therapeutic Advances in Gastroenterology
JF - Therapeutic Advances in Gastroenterology
IS - 3
ER -
