What goes around comes around: Novel pharmacological targets in the gut-brain axis

Camila González-Arancibia, Jorge Escobar-Luna, Camila Barrera-Bugueño, Camilo Díaz-Zepeda, María P. González-Toro, Loreto Olavarría-Ramírez, Francesca Zanelli-Massai, Martin Gotteland, Javier A. Bravo, Marcela Julio-Pieper

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

16 Citas (Scopus)

Resumen

The gut and the brain communicate bidirectionally through anatomic and humoral pathways, establishing what is known as the gut-brain axis. Therefore, interventions affecting one system will impact on the other, giving the opportunity to investigate and develop future therapeutic strategies that target both systems. Alterations in the gut-brain axis may arise as a consequence of changes in microbiota composition (dysbiosis), modifications in intestinal barrier function, impairment of enteric nervous system, unbalanced local immune response and exaggerated responses to stress, to mention a few. In this review we analyze and discuss several novel pharmacological targets within the gut-brain axis, with potential applications to improve intestinal and mental health.

Idioma originalInglés
Páginas (desde-hasta)339-353
Número de páginas15
PublicaciónTherapeutic Advances in Gastroenterology
Volumen9
N.º3
DOI
EstadoPublicada - 2016
Publicado de forma externa

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